Combined Flow and Pressure Measurements in Coronary Artery Disease

All rights reserved. No part of this publication may be reproduced or transmitted in any form by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval systen, without written permission from the copyright owner. Financial support by the Netherlands Heart Foundation for the publication of this thesis is gratefully acknowledged. The study described in this thesis was supported by a grant of the Netherlands Heart Foundation (NHF 98-102) ! " ! ! # $ ! ! ! !% & & ' (! !) %) ! ! ! " % * ! + ! ! * ! " ! % ' ' PART 1: the v-dp relation to assess the hemodynamic significance of a coronary stenosis CHAPTER 2 The diastolic flow velocity-pressure gradient relationship in coronary stenoses in humans 27 CHAPTER 3 The diastolic flow velocity-pressure gradient relation and dp v50 to assess the hemodynamic significance of coronary stenoses 43 editorial Physiological severity of coronary artery stenosis 61 CHAPTER 4 Characteristics of the flow velocity-pressure gradient relation in the assessment of stenoses: an in vitro study 69 PART 2: assessment of the microvascular resistance CHAPTER 5 The diastolic distal coronary pressure-flow velocity relation assessment of myocardial microvascular function and resistance